GPCR Target Tracking & Status

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GPCR Net ID

Protein Name

Uniprot

Ligand/Lattice

Cloning

Expression

Purification

Crystallization

Diffraction

Structure

Refinement

PDB

1*

5-hydroxytryptamin (serotonin) receptor 1A

P08908

 

 

 

 

 

 

 

 

 

2

5-hydroxytryptamin (serotonin) receptor 2C

P28335

 

 

 

 

 

 

4

5-hydroxytryptamine receptor 2B

P41595

Ergotamine

 

 

 

 

 

4IB4

6

adenosine A2a receptor

P29274

ZM241385

 

 

3EML

UK-432097

3QAK

ZM241385

(1.8 Ang)

4EIY

11*

Angiotensin II receptor 1

P30556

 

 

 

 

 

 

 

 

 

15

beta-2-adrenergic receptor

P07550

Carazolol

2RH1

Timolol

3D4S

Alprenolol

3NYA

ICI 118,551

3NY8

Compound1

3NY9

16

beta-3-adrenergic receptor

P13945

 

17*

Blue sensitive opsin

P03999

 

 

 

 

 

 

 

 

 

25

cannabinoid receptor 1  (CB1)

P21554

 

27U

CCR1

P32246

 

28*U

CCR5

P51681

Maraviroc

4MBS

31U

CXCR1

P46094

 

32U

CXCR2

P25025

 

33*U

CXCR3

P49682

 

34*U

CXCR4

 

CVX15

3OE0

 

IT1t

3ODU

P61073

IT1t (I222)

3OE6

 

IT1t (P1)

3OE8

 

IT1t (P1)

3OE9

36

D1 dopamine receptor

P21728

 

38

D3 dopamine receptor

P35462

Eticlopride

3PBL

39*

delta opioid receptor

P41143

Naltrindole

4N6H

48

Ghrelin receptor

Q92847

 

49

Glucagon receptor (GLR)

P47871

4L6R

50

Glucose-dependent insulinotropic receptor

Q8TDV5

 

51*

Gonadotropin-releasing hormone receptor

P30968

 

53

Histamine receptor H1

P35367

Doxepin

 3RZE

56*

kappa opioid receptor

P41145

JDTic

 4DJH

65

Melanocortin 4 receptor

P32245

 

68

Metabotropic glutamate receptor 1

Q13255

 

 

 

 

 

 

 

 

 

71*

mu opioid receptor

P35372

 

74

Neurokinin 1 receptor (Substance P receptor)

P25103

 

79*

nociceptin opioid receptor (ORL-1)

P41146

Compound-24

 4EA3

80

Olfactory receptor 1A1

Q9P1Q5

 

 

 

 

 

 

 

 

 

86

P2Y purinoceptor 1

P47900

 

 

 

 

 

 

 

 

 

87

P2Y purinoceptor 12

Q9H244

AZD1283

 

 

 

 

 

4NTJ

90

Prostaglandin E2 receptor EP2 subtype

P43116

 

 

 

 

 

 

93*

Proteinase-activated receptor 1

P25116

 

 

 

 

 

 

 

 

 

110

Sphingosine 1-phosphate receptor 1

P21453

ML056

3V2W

3V2Y

118*

5-hydroxytryptamine receptor 1B

P28222

dihydroergotamine

 

 

 

 

 

 

 

4IAQ

ergotamine

 

 

 

 

 

 

 

4IAR

119

Olfactory receptor 51L1

Q8NGJ5

 

 

 

 

 

 

 

 

 

120

Olfactory receptor 10A6

Q8NH74

 

 

 

 

 

 

 

 

 

121

Olfactory receptor 2A25

A4D2G3

 

 

 

 

 

 

 

 

 

122

Olfactory receptor 5K1

Q8NHB7

 

 

 

 

 

 

 

 

 

123*

Red-sensitive opsin

P04000

 

 

 

 

 

 

 

 

 

124*

Green-sensitive opsin

P04001

 

 

 

 

 

 

 

 

 

125*

Parathyroid hormone 1 receptor

Q03431

 

 

 

 

 

 

 

 

 

126*

Corticotropin-releasing factor receptor 1

P34998

 

 

 

 

 

 

 

 

 

127*

PACAP-R1

P41586

 

 

 

 

 

 

 

 

 

128

Metabotropic glutamate receptor 4

Q14833

 

 

 

 

 

 

 

 

 

129

Metabotropic glutamate receptor 5

P41594

 

 

 

 

 

 

 

 

 

130

Metabotropic glutamate receptor 7

Q14831

 

 

 

 

 

 

 

 

 

131

Smoothened Receptor

Q99835

LY2940680

 

 

 

 

 

 

 

4N4W

Cyclopamine

 

 

 

 

 

 

 

4O9R

*Entries are Community Nominated Targets, UEntries are U01 Targets, Targets are being pursued with collaborators